Drugs That Reduce Stomach Acid Secretion – Proton Pump Inhibitors (PPIs) – Increase Risk For Diabetes

The single most important thing you can do to prevent diabetes is lose weight. It almost doesn’t matter how – diet, exercise, fasting, surgery. I advocate a low-fat, plant-based diet because it improves health in so many other ways. But it’s not the only way to lose weight.

There are other factors that increase risk for diabetes besides being overweight … family history, having diabetes while pregnant, air pollution, exposure to endocrine disruptors (like BPA) and other environmental pollutants. And now, taking PPIs:

Regular Use Of Proton Pump Inhibitors And Risk Of Type 2 Diabetes: Results From Three Prospective Cohort Studies, BMJ Gut, September 2020

Conclusions: Regular use* of proton pump inhibitors (PPIs) was associated with a higher risk of type 2 diabetes and the risk increased with longer duration of use. Physicians should therefore exercise caution when prescribing PPIs, particularly for long-term use.

* Regular use was defined as 2 or more times a week

Regular Use Of Acid Reflux Drugs Linked To Heightened Risk Of Type 2 Diabetes, BMJ Newsroom, 28 September 2020

PPIs are used to treat acid reflux, peptic ulcers, and indigestion. They are among the top 10 most commonly used drugs worldwide. Long-term use has been linked to an increased risk of bone fractures, chronic kidney disease, gut infections and stomach cancer.

A mounting body of evidence suggests that changes in the type and volume of bacteria in the gut (the microbiome) may help explain the associations found between PPI use and an increased risk of developing diabetes.

Examples of PPIs:
Omeprazole (Prilosec)
Lansoprazole (Prevacid)
Esomeprazole (Nexium)

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