Glyphosate, the active ingredient in the herbicide Roundup, is an endocrine disruptor, as is Roundup itself. In fact, the Roundup formulation is more harmful owing to “inert” ingredients that enhance glyphosate uptake:
Glyphosate-Based Herbicides Are Toxic And Endocrine Disruptors In Human Cell Lines, Toxicology, August 2009
In conclusion, according to these data and the literature, Glyphosate-based herbicides present DNA damages and CMR [carcinogen, mutagen and reprotoxic] effects on human cells and in vivo. … These herbicide mixtures also present ED [endocrine disruptor] effects on human cells, at doses far below agricultural dilutions and toxic levels on mitochondrial activities and membrane integrity. These doses are around residual authorized levels in transgenic feed, and this paper is the first clear demonstration of these phenomena in human cells.
Endocrine Disruption And Cytotoxicity Of Glyphosate And Roundup In Human JAr Cells In Vitro, Integrative Pharmacology, Toxicology and Genotoxicology, 2015
Endocrine disruption effects were secondary to cytotoxicity. Roundup was more cytotoxic than the same concentration of glyphosate alone, indicating that the other constituents of the herbicide are not inert. There is a compelling need to conduct in vivo studies to characterise the toxicity of glyphosate in a Roundup formulation, to facilitate re-evaluation of existing public health guidelines.
Cytotoxicity was observed in vitro after exposure to a range of concentrations comparable to the Australian Drinking Water Guidelines.
So, glyphosate and Roundup are endocrine disruptors, they disrupt metabolism at levels below that allowed in food and water.
You would think our goal then would be to use less glyphosate on crops. Yes? Stay tuned for my next post.